McCormick & Schmick's on Baltimore's inner harbor is where I always take the wife for special occassions and we absolutely love it. One word of caution though: we ordered an amaretto sour at the bar and the bartender made it fresh and delicious; but when we ordered another at the table he obviously used sweet & sour mix instead of fresh squeezed lime.
Pros: fish selection, drinks at the bar, dessert
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