The California Science Center does have a good location, being right by USC (I know, not always considered to be the best area but the California Science Center is safe). There are many other touristy things to do in the area. The science center itself has an array of exhibits which vary so make sure to call ahead of time to see what is currently on display. They always have a dearth of hands on exhibits which children love. The museum is a great place for kids, and while it is no Smithsonian (sorry, Im from Washington, DC) it is a great place to spend a couple of hours with kids. Fun, entertainment, and educational!!
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