Los Angeles offers a world-class selection of attractions for the weekend visitor, from the Santa Monica boardwalk and 3rd St. Promenade in the far west to the Disney Concert Hall downtown, with the Getty Center, the Los Angeles County Museum of Art and several major movie studios in between. Unfortunately, given their broad dispersion from east to west, no single hotel location offers easy access to all these destinations.
If you're looking for a top-flight hotel that minimizes your drive time while offering the richest possible set of activites right out your door, I highly recommend the Mondrian in West Hollywood. Located right on Sunset, the Mondrian is a destination in itself - the rooftop Skybar is one of the hottest watering holes in LA - and offers a central point from which to venture both east and west. In addition, the Sunset Strip and West Hollywood in general offer some of the most interesting street life in all of LA, with hundreds of great stores, coffee shops, music venues and bars all clustered within a few square miles.