I like the Union/S 23rd Target store for several reasons - it's convenient, being close to my house by bus - and they have good prices and a fairly decent selection. Plenty of checkout lines, as well, and they're usually staffed with enough clerks to get you out of the store in a reasonable amount of time. A small food court provides snacks if you wish, and the store is large and bright.
I especially like the home decor section, for they have things that some of the other store don't seem to carry, and at a good price.
The video/DVD section is quite large, as well.