Uncle Sven's my neighborhood's comic shop. While it's small in size has a surprising amount of back issues and wonderful customer service. I've not had any problems finding new issues of mainline titles either--in fact if it's big brother The Source* has sold out of a first-run book, the first place I call is Sven's. It's charming in every sense and a gem from a bygone age.
They also have a limited supply of gaming products, enough to get you started on a Saturday night without making a run out to The Source. And, of course, Sven's has the same great customer service as the mothership!
*The Source Comics and Games and Uncle Svens are owned by the same parent company.
Pros: Great customer service
Cons: Limited selection due to size, but still pretty good