For a pre-wedding Friday night out, we had the party bus pick us up at the hotel and take us to a bunch of clubs in the city. They have agreements with many of the clubs to get in free and get right in (no waiting in line). We brought our own alcohol on the bus and utilized the satellite radio. We we dropped back at the hotel at the end of the night, so no one had to worry about driving anywhere.
The company also has smaller transportation options.