We're the Best Among Picayune, Mississippi Hotels Ideally located along I-59 at exit 4, the Holiday Inn Express Hotel & Suites Picayune is a great home base for area travelers since it's close to Slidell and a short drive from New Orleans. Picayune, Mississippi offers our hotel's patrons fascinating natural attractions, close proximity to area businesses and easy access to Stennis International Airport (HSA) and Amtrak.Leisure guests staying at our hotel's location in Picayune, MS can explore local attractions, Crosby Arboretum, historic downtown, terrific golf courses and Stennis Space Center or venture to the Big Easy for a day trip to the French Quarter, the Riverwalk, the Aquarium of the Americas or the New Orleans Convention Center. Pearl River County offers great shopping, too, with antique stores around every corner and the North Shore Square Mall just minutes away.