About Appleton Comprehensive Treatment Center in Appleton, WI Appleton Comprehensive Treatment Center (CTC), located in Appleton, Wisconsin, offers medication-assisted treatment (MAT) to adults of all genders who are struggling with opioid use disorder, the clinical term for opioid addiction. You may expect a methadone clinic to offer only one type of medication. At Appleton Comprehensive Treatment Center, we give our patients several options, including buprenorphine, methadone, Suboxone, and naltrexone. We also provide individual and group therapies to help our patients address the underlying causes behind their opioid use.