I'm a big fan of Goose Island, especially the Clybourn location. It features an extensive beer list full of Goose Island brews. I tend to stick to just a few, but for you beer connoisseurs out there, you'll get a kick out of this place. The food that Goose Island serves is fantastic. My favorite appetizer is the nacho plate; the cheese is served inside a bread bowl surrounded by chips with your choice of toppings. The bread bowl can even be eaten if you are so inclined (& it's very tasty). Also on the menu is a delicious chicken pot pie that can easily last for two meals. There is a nice mix of sandwiches and home cooked favorites served with a flair.
There are two locations in Chicago - Clybourn and Wrigleyville. Both offer pretty much the same thing but I prefer the ambiance of the Clybourn location. Plus they have a parking lot, which is key in Chicago.