This thrift store has a nice variety of items available. The store is easy to get in and out of (unless you're turning left onto Bay St.). I have found good deals on some items here ranging from electric keyboards to kitchen items. Buyer beware, though. Be sure to check out the electrical items prior to purchasing them.
A great time to shop here is around the year-end holiday season. They usually have a nice variety of decorations available.
I have tried to donate twice to St. Vinnie's and received difficulty in return. Go figure.