Every time I visit my hometown of Pittsburgh, I have to visit Primanti's. This restaurant, conveniently located near the University of Pittsburgh campus in Oakland, is close to but not the same as the original in the Strip. There's a nice lofted seating area, which gives a little more table room. I've noticed that it's quite popular around lunchtime and dinner time with the locals, and late into the evening with the college crowd. If you can't make it to the Strip, this will do; otherwise, save your appetite for the real deal.
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