I found Lupi's on a business trip to Chattanooga nearly 10 years ago, and I make it a point to return whenever I'm NEAR C-town, it's that good. Go for the calzone -- if you've never had one, it's the gold standard for size (football-sized), freshness, and topping availability. Beer selection is great, and my daughter loves the Stewart's sodas available, too. Laid-back atmosphere, great food... just go.
Pros: Fresh food, Good Beer, Different atmosphere
Cons: Can be crowded, Calzones TOO big?