When you enter Home Depot, you will get a sense of largeness and a hurried bustle, as well as the color orange. (grin) But in my own experience, I have found the staff at Home Depot to be the more helpful of any of the other hardware stores.
The selection is very extensive, although not perhaps as big as their neighbor. It should suffice for many needs, though.
They also have a large collection of home decor items such as carpeting and wallpaper.