I transferred to UCI and began my upper-division college studies as an English major this January, and what an experience it has been! There are excellent resources on campus: wireless internet access just about everywhere you go, internship opportunities, counseling (career and personal), peer advisors...there are more resources than I can even begin to list, but if you ask, someone will be sure to point you in the right direction. UCI is particularly sensitive to the transfer student, and there are plenty of opportunities to ask for assistance, which I highly recommend. Their website provides a great deal of information whatever your major.
The quarter system is great: I came from the semester system and there is no opportunity for boredom to enter into one's vocabulary as you blaze through your classes. This also means: Don't Procrastinate!
The hardest thing for me is balancing work and school. Most classes are offered as Mon/Wed/Fri OR Tues/Wed, and evening classes for the upper division coursework required of English majors is rare, so be aware if you are looking to balance a job that pays for more than your basic extra-curricular activities. It is possible, though. Having survived the first quarter with my head still attached, I feel confident that others will have great success if they are returning to school from a long hiatus (I graduated high school in 1995).
Parking is tough at times, so I recommend allowing yourself (especially the first week of classes) plenty of time to park and get to your classrooms. Tuesdays & Thursdays, I'm told, are the busiest parking days.
Overall, it's a great school and I feel especially blessed to have such a wonderful university so close to home. Go Anteaters!