This thrift store is my favorite in the San Deigo area so far. It is smaller than many thrift stores and that is probably the only negative about them.
The people working/volunteering there are very friendly and helpful. They always have a good selection of items. Their books are priced inexpensively ($0.25 for kids books and $0.50 for adult paperbacks) and they are constantly getting new ones. They have a separate entrance for clothing and always have an interesting selection for adults and kids alike.
As for donations, I always feel good donating to them because of the cause they support (woman escaping domestic violence situations). They help unload my car and will even come to your home to pick up donations with no hassle.