I'm not one of these people who feels a deep obligation to independent book stores. In general, I think the combination of Borders, Barnes & Noble, and Amazon has been great for readers. Book shopping is a hundred times better in most places than it was when I was young.
All that said, I have to tell you that Wordsworth is still my favorite book store. I always enjoy browsing there because the staff seems to do a better job of selecting interesting books to display than any other place I have been. I'm always encountering stuff I wouldn't have found myself but am glad to pick up, page through, and occasionally buy. They just have great taste there.