I was lucky enough to live about 2 blocks away from 52.5 when I lived in Charleston. It is THE place to go for out-of-the-mainstream music and videos.
They have video sales, but also a HUGE video & DVD rental section as well. Looking for a film that is so obscure that only 4 other people have seen it? Look no further than 52.5.
Don't know WHAT you want to rent? Take an hour of your time and just browse the aisles. From early talkies & silent films, to 1950's Cheese-Fest Sci-Fi, to 1960's Drug-Enduced Acid Flicks and EVERYTHING inbetween, 52.5 has what you're looking for.
Their staff is cool, but not pretentious. They have every right to be, though, because they work at one of the few remaining non-corporate music & video stores left in Charleston. When you walk into 52.5, remember that this is what Charleston used to be like 15 years ago, before GAP and Banana Republic and Books-A-Million moved in and made all the locally owned bohemian shops close down.