The San Diego Museum of Art is the region largest and oldest art museum. They have an extensive collection of European art, 19th and 20th century American art, and a fine collection of Asian art. Additionally, like any art museum, they have rotating exhibits. Currently they have the art of Maxfield Parrish, the most published and recognizable American artist. Going on one of the docent tours is the best way to learn all about Parrish. On a recent visit, I got to learn about his life and the subjects of most of his art pieces (oak trees and Sue Lewin). Definitely worth a visit.
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