A great place to get away from, oh, New York, for instance. Indulge yourself in a suite if possible, (which are not outrageously priced at $500+) -- ESPECIALLY if you have kids! The food and service are worth raving about, and the Inner Harbor location is just icing on the cake. If you're on a budget, check out the package room rates. My only nit about this hotel is the high daily parking fees it tacks on if you drive there.
Pros: great rooms, great food, great service