If you're looking for a hotel that is close to the beach, within walking distance to almost everything you'll want to do....HoJo's Tybee is the place. It's clean, quiet, and cheap for a few days on the island. Staff is very helpful and friendly. The beach is a short walk from the front door, all the major breakfast places are adjacent to the hotel, and "downtown" Tybee is 1 block away. There are some other hotels there...the Super 8 is, well "loud" and the Roadway is a tad dated. I was very happy with my experience there and would definitely go back.
Pros: close to everything, reasonably priced, parking on property
Cons: sells out quickly