I used to go there all the time when I was on the Upper West Side. Fantastic for big-screen Hollywood fare, with the occasional smaller film showing. Great layout as far as theaters go, extremely spacious. More upscale crowd than the Times Square theaters. If you're looking for dinner or afterwards or a good book, nearby Ollie's and Barnes & Noble provide other great local options.
Pros: space! Even sitting in the front row, I wasn't bothered by the screen